A Review on Role of Itrifal-e-Ustukhuddus in Management of Cervical Spondylosis

Cervical spondylosis is a progressive degenerative disorder of the cervical spine, frequently associated with aging and lifestyle factors. It commonly presents with neck discomfort, stiffness, and sometimes nerve-related symptoms such as pain radiating to the arms, numbness, or weakness. Conventional management focuses on symptom control through pharmacotherapy, physiotherapy, and, in advanced stages, surgery. However, these interventions may have limitations, especially for long-term management. In Unani medicine, cervical spondylosis corresponds to Wajaʿ al-Raqaba and is understood to arise from a predominance of cold and dry temperament affecting the cervical region, resulting in obstruction of nerve and vascular pathways. Among the classical herbal formulations, Itrifal-e-Ustukhuddus has been widely used for disorders of the nervous system, chronic headaches, and musculoskeletal ailments. It contains ingredients with proven anti- inflammatory, neuroprotective, and analgesic properties. This review compiles current understanding from both modern and Unani perspectives, explores the pharmacological basis of Itrifal-e-Ustukhuddus, and discusses its therapeutic potential in managing cervical spondylosis.