Integration of Ultrafast Laser Therapy and MicroRNA (miRNA)-Based Precision Medicine for Chronic Pain Management in Kyrgyzstan: A Long One Year Multi-Regional Study with Advanced Mathematical and Scientific Modeling

This study proposes a new modality of ultrafast laser therapy and microRNA (miRNA)-based personalized therapy for managing chronic pain, with a target for optimized efficacy in Kyrgyzstan. With cutting-edge bioinformatics, laser technology, and genetic analysis, the work compares efficacy of such a dual modality therapy in seven regions, in terms of demographics, working profiles, and access to care in each region. With high-facilitated mathematics and algorithms, therapy protocols for individual therapy for optimized pain, reduced addiction to opioids, and with multi- dimensional factors in managing chronic pain, individual therapy protocols become a necessity. With a 5,000-patient cohort, the work reveals a high 78% improvement in pain, translating to a 42% improvement in patient outcomes. Efficacy is age-dependent, occupations-dependent, and geographical locations-dependent, and localized, fact-dependent interventions become important. With a new modality, a model for a technology-intensive, personalized, and scalable model for managing chronic pain with a target for individualized care and high-tech integration for optimized patient care and reduced use of conventional killers comes into consideration.